Prescribing overview
Credelio and Credelio CAT are separately labeled single-ingredient products; Quattro is a different combination.
Key prescribing checks
- Review seizure or neurologic history because isoxazolines carry neurologic adverse-event precautions. Discuss prior preventive reactions before selecting another product in the class.
- Confirm species, weight, age, target parasites and food-related administration instructions from the exact label. Feline tick eligibility is not identical to feline flea eligibility.
- Single-ingredient Credelio does not become a heartworm or intestinal-worm preventive by sharing a family name with Quattro. Emergency-use authorizations and conditional approvals are distinct from ordinary approved indications and require checking the current regulatory terms.
Uses by species
Approval and evidence apply to the named product, species, route and indication. An extra-label use requires its own prescribing assessment; a human indication is not an animal approval.
Dogs
FDA-approved veterinary labelFleas and label-listed ticks; prevention of B. burgdorferi infection by killing vector ticks
≥8 weeks, ≥4.4 lb.
Use / indication source ↗Cats
FDA-approved veterinary labelFleas; black-legged ticks
Fleas: ≥8 weeks; ticks: ≥6 months; both ≥2 lb.
Use / indication source ↗Pharmacology & pharmacokinetics
Mechanism and clinical role
Inhibits arthropod GABA-gated chloride channels.
Absorption, distribution, metabolism and elimination
Food improves exposure; canine half-life varies with age and must not be transferred to cats.
SAFETY REFERENCE · PRODUCT & SPECIES SPECIFIC
Contraindications & cautions
Contraindications identify circumstances where the source says a product should not be used. Precautions call for assessment or monitoring. Interactions identify combinations to review. They are distinct categories; this summary does not replace a full interaction check or the current product label.
Credelio
Dogs; single-ingredient oral chewable
Contraindications · when not to use
- The label reports no known contraindications.
Precautions & monitoring
- Use cautiously with seizure or neurologic history; neurologic reactions can occur without prior history. Reproductive safety is unevaluated.
Credelio CAT
Cats; single-ingredient oral tablet
Contraindications · when not to use
- The label reports no known contraindications.
Precautions & monitoring
- Use cautiously with neurologic history; reactions can occur without prior history. Reproductive safety is unestablished.
Age, weight and parasite eligibility remain product specific. These entries do not cover Credelio Quattro.
Safety sources checked: . Selected label information; independent veterinary or veterinary-pharmacy review remains pending. A label for dogs, cats, horses or humans does not establish safety for another species.
Adverse effects
Isoxazolines can cause tremors, ataxia or seizures even without prior history.
These are selected source-reported effects, not incidence estimates or an exhaustive list. Spontaneous postmarketing reports do not by themselves establish frequency or causality.
Dosing & administration
| Species & indication | Labeled regimen | Eligibility & source |
|---|---|---|
| Dogs ≥8 weeks and ≥4.4 lbLabeled flea/tick controlCredelio chewable tablets | Minimum 20 mg/kg Oral with food · Monthly May continue year-round | Use canine label weight bands. Verify full dosing label ↗ |
| Cats meeting indication-specific age and weight limitsLabeled flea/black-legged tick controlCredelio CAT chewables | Minimum 6 mg/kg Oral with food · Monthly May continue year-round | Use feline weight bands. Verify full dosing label ↗ |
Emergency-use screwworm provisions are not ordinary approved flea/tick indications and are not dosed here.
Extra-label prescribing and food-animal residue requirements are separate from labeled regimens. FDA extra-label-use guidance ↗
Drug & supplement interactions
This is a selected interaction reference, not an automated or comprehensive combination checker. Reconcile prescription drugs, nonprescription products, supplements and recent treatment changes.
A product-specific interaction summary has not been established here. An empty list must not be interpreted as “no interactions.” Review the full source and a species-appropriate clinical reference.
Monitoring
Review neurologic history and response.
Client counseling
Report neurologic changes; confirm complete consumption.
This section supports the veterinary team's discharge discussion; it does not replace the product’s Client Information Sheet where one is required.
Storage & handling
Secure labeled packages against accidental ingestion.
Brands, formulations & ingredient identity
Active ingredients
Lotilaner
Credelio identifies the canine lotilaner product; Credelio CAT is a separately labeled feline presentation. The shared ingredient does not make tablets interchangeable across species.
Credelio Quattro contains additional actives: moxidectin, praziquantel and pyrantel. It is a combination product rather than a generic synonym for single-ingredient lotilaner.
Shared ingredients do not establish interchangeable concentrations, routes, release properties, species labeling or regional availability.
Credelio
- Formulation
- Oral chewable tablets
- Label / product scope
- Dogs
Single-ingredient canine lotilaner product.
Product label / source ↗Credelio CAT
- Formulation
- Oral tablets
- Label / product scope
- Cats
Separate feline labeling; distinct from Credelio Quattro.
Product label / source ↗References & review status
Clinical reference updated October 16, 2026. Independent veterinary or veterinary-pharmacy review not yet completed. Evidence gaps remain explicitly identified; this page does not claim equivalence to a comprehensive, professionally reviewed veterinary formulary.