Prescribing overview
Revolution Plus is feline topical combination therapy, not interchangeable with Revolution or canine Simparica.
Key prescribing checks
- The U.S. product is for cats and kittens meeting the label age and weight requirements, not an interchangeable dog preparation.
- Isoxazoline labeling includes potential neurological reactions, including tremors, incoordination and seizures. Review neurological history and counsel about new signs.
- Safety has not been established in breeding, pregnant or lactating cats. Review the complete label for patient eligibility and species-specific parasite claims.
Uses by species
Approval and evidence apply to the named product, species, route and indication. An extra-label use requires its own prescribing assessment; a human indication is not an animal approval.
Cats
US FDA-approved Revolution PlusHeartworm prevention; label-listed roundworms, hookworms, ear mites, fleas and four tick species; Dipylidium prevention through flea-vector killing
At least eight weeks old and 2.8 lb.
Use / indication source ↗Pharmacology & pharmacokinetics
Mechanism and clinical role
Selamectin disrupts parasite chloride conductance; sarolaner blocks arthropod ligand-gated chloride channels.
Absorption, distribution, metabolism and elimination
After feline topical combination administration, reported half-lives are 12.5 days for selamectin and 41.5 days for sarolaner; both distribute systemically.
SAFETY REFERENCE · PRODUCT & SPECIES SPECIFIC
Contraindications & cautions
Contraindications identify circumstances where the source says a product should not be used. Precautions call for assessment or monitoring. Interactions identify combinations to review. They are distinct categories; this summary does not replace a full interaction check or the current product label.
Revolution Plus
Topical combination solution; Cats
Contraindications · when not to use
- Label reports no known contraindications.
Precautions & monitoring
- Use caution with neurologic history; seizures may occur without prior history. Safety below eight weeks or in breeding, pregnant or lactating cats has not been evaluated.
Safety sources checked: . Selected label information; independent veterinary or veterinary-pharmacy review remains pending. A label for dogs, cats, horses or humans does not establish safety for another species.
Adverse effects
Application-site reactions, vomiting, anorexia and lethargy; tremors, ataxia and seizures can occur.
These are selected source-reported effects, not incidence estimates or an exhaustive list. Spontaneous postmarketing reports do not by themselves establish frequency or causality.
Dosing & administration
| Species & indication | Labeled regimen | Eligibility & source |
|---|---|---|
| CatsLabel-listed parasite prevention/controlRevolution Plus single-dose tubes | Minimum selamectin 6 mg/kg plus sarolaner 1 mg/kg; whole weight-band tube(s) Topical skin application · Monthly One month per dose; continue according to parasite exposure/prevention plan | At least eight weeks and 2.8 lb. For >22 lb use the label-directed tube combination. Verify full dosing label ↗ |
Breeding/pregnancy/lactation safety is unestablished; use caution with neurologic history.
Extra-label prescribing and food-animal residue requirements are separate from labeled regimens. FDA extra-label-use guidance ↗
Drug & supplement interactions
This is a selected interaction reference, not an automated or comprehensive combination checker. Reconcile prescription drugs, nonprescription products, supplements and recent treatment changes.
A product-specific interaction summary has not been established here. An empty list must not be interpreted as “no interactions.” Review the full source and a species-appropriate clinical reference.
Monitoring
Review heartworm prevention history, parasite response and new neurologic signs.
Client counseling
Apply directly to dry neck-base skin, not broken skin; do not massage or give orally.
This section supports the veterinary team's discharge discussion; it does not replace the product’s Client Information Sheet where one is required.
Storage & handling
Store at or below 30°C; avoid flame/heat until dry.
Brands, formulations & ingredient identity
Active ingredients
Selamectin · Sarolaner
Revolution Plus is not simply another name for Revolution: it adds sarolaner to selamectin.
The topical feline combination is also distinct from oral canine Simparica, although both contain sarolaner.
Shared ingredients do not establish interchangeable concentrations, routes, release properties, species labeling or regional availability.
Revolution Plus
- Formulation
- Topical combination solution
- Label / product scope
- Cats
Two active ingredients; retain the Plus suffix when documenting or dispensing.
Product label / source ↗References & review status
Clinical reference updated October 16, 2026. Independent veterinary or veterinary-pharmacy review not yet completed. Evidence gaps remain explicitly identified; this page does not claim equivalence to a comprehensive, professionally reviewed veterinary formulary.
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