Prescribing overview
Revolution is a selamectin-only topical product; parasite coverage differs between dogs and cats.
Key prescribing checks
- Review the species-specific label and age limits before dispensing; the U.S. label starts at six weeks for dogs and eight weeks for cats.
- The label excludes sick, debilitated or underweight animals. Evaluate health status instead of treating all weight-matched patients alike.
- Heartworm assessment and preventive history must be reviewed according to the label and veterinary plan. Topical placement is not an oral administration instruction.
Uses by species
Approval and evidence apply to the named product, species, route and indication. An extra-label use requires its own prescribing assessment; a human indication is not an animal approval.
Dogs
US FDA-approved RevolutionFleas, heartworm prevention, ear mites, sarcoptic mange and Dermacentor variabilis ticks
Dogs at least six weeks old.
Use / indication source ↗Cats
US FDA-approved RevolutionFleas, heartworm prevention, ear mites, Toxocara cati and Ancylostoma tubaeforme
Cats at least eight weeks old.
Use / indication source ↗Pharmacology & pharmacokinetics
Mechanism and clinical role
Macrocyclic-lactone activity prevents development of susceptible immature heartworms; not an adult-heartworm treatment.
Absorption, distribution, metabolism and elimination
Quantitative species-specific disposition is not established by the reviewed single-ingredient label.
SAFETY REFERENCE · PRODUCT & SPECIES SPECIFIC
Contraindications & cautions
Contraindications identify circumstances where the source says a product should not be used. Precautions call for assessment or monitoring. Interactions identify combinations to review. They are distinct categories; this summary does not replace a full interaction check or the current product label.
Revolution
Topical solution; Dogs, Cats
Contraindications · when not to use
A formal contraindication list is not established in the reviewed source for this scope. This does not establish safety; confirm the exact product and full labeling.
Precautions & monitoring
- Animal safety warning: do not use in sick, debilitated or underweight animals. Test dogs for existing heartworm infection; this is not adult-heartworm treatment.
The label states the health-status exclusion under Warnings, rather than a separate Contraindications section.
Safety sources checked: . Selected label information; independent veterinary or veterinary-pharmacy review remains pending. A label for dogs, cats, horses or humans does not establish safety for another species.
Adverse effects
Transient application-site hair loss/irritation, digestive signs and neurologic reactions have been reported.
These are selected source-reported effects, not incidence estimates or an exhaustive list. Spontaneous postmarketing reports do not by themselves establish frequency or causality.
Dosing & administration
| Species & indication | Labeled regimen | Eligibility & source |
|---|---|---|
| Dogs ≥6 weeks; cats ≥8 weeksFlea control and heartworm preventionRevolution species/weight-specific single-dose tubes | Minimum 6 mg/kg; entire labeled weight-band tube(s) Topical skin application · Monthly Flea season; heartworm prevention year-round or through one month after last mosquito exposure | Do not use in sick, debilitated or underweight animals. Other parasite courses have separate label instructions. Verify full dosing label ↗ |
Tube concentrations differ; do not select by volume alone.
Extra-label prescribing and food-animal residue requirements are separate from labeled regimens. FDA extra-label-use guidance ↗
Drug & supplement interactions
This is a selected interaction reference, not an automated or comprehensive combination checker. Reconcile prescription drugs, nonprescription products, supplements and recent treatment changes.
A product-specific interaction summary has not been established here. An empty list must not be interpreted as “no interactions.” Review the full source and a species-appropriate clinical reference.
Monitoring
Assess heartworm history/testing and ongoing parasite response.
Client counseling
Apply to visible dry skin at the neck base; never give orally.
This section supports the veterinary team's discharge discussion; it does not replace the product’s Client Information Sheet where one is required.
Storage & handling
Store below 30°C; keep away from heat/flames.
Brands, formulations & ingredient identity
Active ingredients
Selamectin
Revolution contains selamectin alone; Revolution Plus contains selamectin and sarolaner and is a separate combination product.
Tube size and species labeling remain essential identity fields. A brand-family match is not enough to select a product.
Shared ingredients do not establish interchangeable concentrations, routes, release properties, species labeling or regional availability.
Revolution
- Formulation
- Topical solution
- Label / product scope
- Dogs · Cats
Selamectin-only product; parasite coverage is species-specific.
Product label / source ↗References & review status
Clinical reference updated October 16, 2026. Independent veterinary or veterinary-pharmacy review not yet completed. Evidence gaps remain explicitly identified; this page does not claim equivalence to a comprehensive, professionally reviewed veterinary formulary.
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